Key result
In a rat model of type 2 diabetes, the diabetic condition was discriminated by a high-frequency shift in carotid sinus nerve and sympathetic nervous system neural activities, and inter-burst intervals strongly correlated with glycaemia levels.
Why the study?
A robust characterization of the relationship between CSN and SNS neural activities and metabolism in type 2 diabetes was still missing.
Does carotid sinus nerve activity correlate with glycaemic alterations in a rat model of type 2 diabetes?
Does carotid sinus nerve activity correlate with glycaemic alterations in a rat model of type 2 diabetes?
Carotid sinus nerve neural activity correlates with glycaemic alterations and could potentially serve as a marker for closed-loop neuromodulation in type 2 diabetes.
May support neural biomarkers for glycaemic monitoring in diabetes; hypothesis-generating for closed-loop neuromodulation pending human studies.
Recent studies showed that the carotid sinus nerve (CSN) and the sympathetic nervous system (SNS) are overactivated in type 2 diabetes and that restoring the correct CSN neural activity can re-establish the proper metabolism. However, a robust characterization of the relationship between CSN and SNS neural activities and metabolism in type 2 diabetes is still missing. Here, we investigated the relationship between neural activity of CSN and SNS in control rats and in rats with diet-induced type 2 diabetes and the animal condition during metabolic challenges. We found that the diabetic condition can be discriminated on the basis of CSN and SNS neural activities due to a high-frequency shift in both spectra. This shift is suppressed in the SNS in case of CSN denervation, confirming the role of CSN in driving sympathetic overactivation in type 2 diabetes. Interestingly, the Inter-Burst-Intervals (IBIs) calculated from CSN bursts strongly correlate with perturbations in glycaemia levels. This finding, held for both control and diabetic rats, indicates the possibility of detecting metabolic information from neural recordings even in pathological conditions. Our results suggest that CSN activity could serve as a marker to monitor glycaemic alterations and, therefore, it could be used for closed-loop control of CSN neuromodulation. This paves the way to the development of novel and effective bioelectronic therapies for type 2 diabetes.
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Cracchiolo et al. (2019) studied Type 2 diabetes (animal model) (n=23). High-fat high-sucrose diet and carotid sinus nerve resection vs. Control diet and sham procedure was evaluated on Neural activity of the carotid sinus nerve (CSN) and sympathetic nervous system (SNS). In a rat model of type 2 diabetes, the diabetic condition was discriminated by a high-frequency shift in carotid sinus nerve and sympathetic nervous system neural activities, and inter-burst intervals strongly correlated with glycaemia levels.
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