Acute toxicity study of water soluble C60 was conducted in young female rats with one dose intraperitoneal injection of C60 ((CH2)4S03Na)4–6. The preliminary results indicated its LD50 value as approximately 600 mg/kg. The compound induced a unique phagolysosome-overload nephropathy that may serve as a biological marker in toxicity screening test for a series of synthesized water-soluble fullerenes.
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Chen et al. (1997) studied this question.
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