Key result
Angiotensin-(1-7) prevented immobilization-induced decreases in muscle strength and myofiber diameter via the Mas receptor and IGF-1/IGFR-1/Akt pathway activation in mice.
Why the study?
Does Angiotensin-(1-7) prevent disuse skeletal muscle atrophy via the Mas receptor in a mouse model of immobilization?
Population
Male, 12-week-old wild-type and Mas-knockout mice undergoing unilateral cast immobilization of the hind limb
Comparison
Angiotensin-(1-7) [Ang-(1-7)] vs Control (immobilization without Ang- or Mas KO…
Design
Preclinical
Follow-up
1 and 14 days
Authors
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Hypothesis-generating for Mas receptor agonism in disuse atrophy; leaves open translation to human immobilization without clinical trials.
Does Angiotensin-(1-7) prevent disuse skeletal muscle atrophy via the Mas receptor in a mouse model of immobilization?
Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy via the Mas receptor and activation of the IGF-1/Akt signaling pathway in a mouse model.
Morales et al. (2016) studied Disuse skeletal muscle atrophy. Angiotensin-(1-7) vs. Control / Mas KO mice was evaluated on Muscle strength, myofiber diameter, and atrophy-related protein expression. Angiotensin-(1-7) prevented immobilization-induced decreases in muscle strength and myofiber diameter via the Mas receptor and IGF-1/IGFR-1/Akt pathway activation in mice.
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