Quantitative studies regarding the fate of parenterally injected digitoxin in the rat were made by assaying extracts of rat tissue by the embryonic duck heart method. The concentration of digitoxin found in heart muscle was similar to that found in lung and kidney and greater than the concentration in skeletal muscle. The greatest amount was found in the liver and suggested the importance of this organ in the excretion or destruction of digitoxin.
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Bine et al. (1951) studied this question.