Key result
Left atrial volume index was significantly higher in dialyzed patients than controls and strongly correlated with QRS-T angle in both hemodialysis (r=0.407, P<0.001) and peritoneal dialysis groups.
Observational (n=120)
Left atrial volume index is significantly elevated in dialysis patients and correlates with ventricular repolarization abnormalities, suggesting its potential as a biomarker for stratifying repolarization disturbances.
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LAVI should not yet inform repolarization risk assessment in dialysis; leaves open its biomarker utility pending prospective validation.
This study was performed to investigate the relationship between left atrium (LA) volume index (LAVI) and left ventricle electrical activity presumably repolarization in end-stage renal disease patients. Study group was consisted of 120 dialyzed patients divided into two subgroups: 57 (age 50.7 ± 7.1) were on continuous ambulatory peritoneal dialysis (CAPD) and 73 (age 51.6 ± 7.6) were hemodialyzed (HD). All patients were undergoing three-dimensional vectorcardiographic (VCG) monitoring to assess parameters concerning T vector: QRS-T angle, Tel, and Taz. Standard echocardiography was performed to assess: LAmax, LAshort, LAlong. LAVI was calculated due to formula: LAVI = (π/6X [LAmax × LAshort × LAlong])/m2. LAVI in HD as well as in CAPD patients was significantly higher compared with controls (respectively: 36.29 ± 10.92; 36.41 ± 11.06; 20.64 ± 6.77 mL/m2). The calculated cutoff value of LAVI was 36.32 mL/m2. In HD patients, the strong correlations between LAVI and QRS-T angle and Tel were determined (respectively: r = 0.407, P < 0.001 and r = 0.359, P = 0.006). Similarly in CAPD group were significant associations between LAVI and QRS-T angle and Tel (respectively: r = 0.423, P < 0.001 and r = 0.374, P = 0.004). The QRS-T angle, Tel and Taz are independently and markedly associated with LAVI in both HD and CAPD patients. LAVI and VCG indices are higher in both HD and CAPD patients. Correlation between QRS-T angle and LAVI may reflect unfavorable influence on the electrical activity of the heart in dialyzed patients with left ventricle diastolic dysfunction. LAVI cutoff value is useful biomarker for stratification of ventricle repolarization disturbances in those patients.
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Zapolski et al. (2012) conducted an observational in End-stage renal disease (n=120). Left atrial volume index (LAVI) vs. Controls was evaluated on Correlation between LAVI and QRS-T angle (r = 0.407, p=<0.001). Left atrial volume index was significantly higher in dialyzed patients than controls and strongly correlated with QRS-T angle in both hemodialysis (r=0.407, P<0.001) and peritoneal dialysis groups.
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