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Nausea and vomiting are common and among the most distressing adverse effects of cytotoxic drugs (1). The mechanisms mediating nausea and vomiting are complex and not completely understood. Control of emesis and nausea is essential for improving the quality of life for patients with acute leukemia who are treated with highly to moderately emetogenic drugs. Tranquillizing or anxiolytic drugs such as dixyrazine and lorazepam have been used for many years for prevention of nausea and vomiting caused by cancer chemotherapy or general anaestesia (2-4).
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Sundström et al. (1997) studied this question.
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