Hyperkalemia, defined as a plasma potassium concentration above 5 mmol/l, is a common electrolyte disturbance1. It is often asymptomatic but may be potentially life-threatening when presenting with severe manifestations including cardiac conduction defects, arrythmias and acute neuromuscular dysfunction. Three main intricate mechanisms are involved in the pathophysiology of hyperkalemia: excessive potassium intake, reduced renal elimination and increased potassium release from the intracellular to extracellular space.
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Mazloum et al. (2026) studied this question.