Further Observations on Age of the Menarche

of cortisone therapy. No remarkable effects were noted by these workers on heart size or blood pressure, but in three cases tachycardia was replaced by bradycardia. The dosages of cortisone used were considerably greater than in the present series; on reducing the daily dosage from 200 mg. to 100 mg. the heart rate increased to normal levels. Hench and his associates offered no explanation of the cardiovascular action of cortisone.