Key result
Carillon system plus CRT-D improves EF by ~10% and NYHA class in a severe FMR case.
Why the study?
Does the Carillon Mitral Contour System followed by CRT-D implantation improve symptoms and echocardiographic parameters in a patient with severe functional mitral regurgitation and severe LV dysfunction?
Case Report (n=1)
No
Does the Carillon Mitral Contour System followed by CRT-D implantation improve symptoms and echocardiographic parameters in a patient with severe functional mitral regurgitation and severe LV dysfunction?
Staged percutaneous mitral annuloplasty using the Carillon system followed by CRT-D implantation safely improved functional status and echocardiographic parameters in a patient with severe functional mitral regurgitation and severe LV dysfunction.
Supports staged Carillon plus CRT-D in severe FMR with LV dysfunction; hypothesis-generating and leaves open need for prospective trials.
Mitral valve regurgitation (MR) is a common problem in patients with cardiac issues especially those with dilated cardiomyopathy (DCM) due to mitral annular dilatation and malcoaptation of the mitral valve leaflets. Although DCM is associated with high mortality rates, there has been no global agreement about the best method of treatment. Treatment of MR in such cases can be done by surgery, which has many limitations due to high-risk concerns. MR may also be managed by other alternatives such as mitral-clip and transcoronary venous mitral annuloplasty using the Carillon® Mitral Contour System®. Combined therapy with a cardiac resynchronization therapy defibrillator (CRT-D) and mitral contour can be used in such cases with valuable improvement in general condition in many patients. In our case, we used the Carillon Mitral Contour System for treatment of severe MR in a 64-year-old patient with severely impaired systolic function after implantation of a CRT-D.
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Said et al. (2018) conducted a case report in Severe functional mitral regurgitation and dilated cardiomyopathy (n=1). Carillon Mitral Contour System and CRT-D implantation was evaluated on NYHA functional class and echocardiographic parameters. Deployment of the Carillon Mitral Contour System followed by CRT-D implantation in a patient with severe functional mitral regurgitation improved ejection fraction from 15% to 25% and NYHA class from III-IV to I at 6 months.
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