Key result
Linking large international cohorts provides a vast digital resource to address global scientific challenges.
Why the study?
Individual large cohorts are constrained by size, ancestral origins, and geographical boundaries, limiting their ability to examine specific subgroups, exposures, outcomes, and interactions alone.
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Expands global cardiovascular research capacity; extends collaborative analyses but leaves clinical translation open.
Large cohort studies involving hundreds of thousands of participants have been established or launched in several regions worldwide. Cohorts provide great value for studying diverse populations and key demographic subgroups, rare genotypes and exposures, and gene-environment interactions.1 Each cohort is constrained, however, by its size, ancestral origins, and geographical boundaries, which limit the subgroups, exposures, outcomes, and interactions it can examine. Linking data across large cohorts provides a vast digital resource of diverse data to address questions that none of these cohorts can answer alone, enhancing the value of each cohort and leveraging the enormous investments made in them to date.
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Manolio et al. (2020) reported a review. Linking data across large international cohorts provides a vast digital resource to address global scientific challenges that individual cohorts cannot answer alone.
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