Indicators of the relationship between heart rate variability and levels of glycemia and cholesterol in vibration pathology

Introduction. Vibration disease (VD) is one of the leaders in the structure of occupational diseases among workers in the coal mining industry. The occurrence of disorders at the systemic level (primarily in the nervous and vascular systems) leads to suppression of heart rate variability (HRV) in vibration pathology as a result of damage to vegetative fi bers, centers, ganglia. The study of metabolic disorders in relation to HRV indicators, including nonlinear ones, is of interest for understanding the mechanisms of the VD, and is also important for fi nding non-invasive and less expensive methods of dynamic control. The aim of the studywas to study the parameters of heart rate variability, total cholesterol and blood glucose levels in patients with vibration disease, to identify the relationship between them. Materials and methods. 75 patients of the Clinic of the Research Institute for Complex Problems of Hygiene and Occupational Diseases subjected to industrial vibration for 10 years or more (the main group) and 20 people of the control group who never had contact with industrial vibration were examined. Th e age of the subjects was 40–60 years. Fasting blood glucose and total cholesterol levels were studied, heart rate variability was studied. Frequency and nonlinear phenomena of heart rate variability were analyzed. Spearman correlation coeffi cient was determined to assess the strength of the relationship between blood and heart rate variability. Results. Glucose and cholesterol levels were statistically higher in the group of patients with vibration disease. Spectral parameters of high — and low-frequency heart rate variability in the main group signifi cantly decreased. In patients with vibration pathology of the approximated entropy was signifi cantly lower, whereas deranty fl uctuation analysis increased. Th ese changes of heart rate variability indicate the involvement of all departments of vegetative nervous system, the development of relative sympathicotonia. Correlations of average strength between heart rate variability and levels of glycemia and cholesterol were revealed. Conclusion.Under the infl uence of industrial vibration in workers’ blood cholesterol and glucose levels increase, heart rate variability is suppressed and correlated with an increase in metabolic disorders.