New 2,5‐disubstituted 1,3,4‐oxadiazole derivatives bearing C‐furyl glycoside moieties and their sugar hydrazone as well as their per‐O‐acetyl derivatives were synthesized starting from ethyl 2‐[5‐(3,4‐dihydroxytetrahydrofuran‐2‐yl)‐2‐methylfuran‐3‐yl]‐2‐oxoacetate. Heterocyclization of the sugar hydrazones using acetic anhydride afforded the corresponding oxadiazoline acyclic C‐nucleosides. The antimicrobial activity evaluation showed that many of the synthesized compounds revealed moderate to high antimicrobial activity. J. Heterocyclic Chem., (2011)
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El‐Sayed et al. (2011) studied this question.
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