Key result
The ADIPOQ -11391A allele was significantly associated with an increased risk of diabetic nephropathy (OR 1.186; 95% CI 1.051-1.338; P=0.006).
Why the study?
Are ADIPOQ gene polymorphisms associated with increased susceptibility to diabetic nephropathy?
Meta-Analysis
Are ADIPOQ gene polymorphisms associated with increased susceptibility to diabetic nephropathy?
The ADIPOQ -11391A allele and the +45T > G polymorphism (in Caucasians) are associated with an increased risk of diabetic nephropathy.
May inform genetic susceptibility screening in diabetes; leaves open clinical utility pending prospective validation.
Adiponectin (ADIPOQ) plays an important role in the pathogenesis of diabetic nephropathy (DN) and previous studies regarding the association between ADIPOQ polymorphisms and DN risk reported conflicting results. To derive a more precise estimation of this association, we performed a meta-analysis to assess the association between four ADIPOQ polymorphisms [-11391G > A (rs17300539), -11377C > G (rs266729), +45T > G (rs2241766), and +276G > T (rs1501299)] and risk for DN. Odds ratios (ORs) with corresponding 95% confidence intervals (95% CIs) were pooled to assess the association between four aforementioned polymorphisms and susceptibility to DN. Based on the included criteria, we selected 13 articles, among which 7 studies (cases/controls: 2749/7585) for -11391G > A, 8 studies for -11377C > G (3074/3842), 9 studies for +45T > G (2654/7710), and 10 studies for +276G > T (2812/7821), respectively. Our meta-analysis indicated no evidence heterogeneity among the included studies; thus, the fixed-effects model was used. Overall, there was an association between ADIPOQ -11391A allele with increased DN risk (OR = 1.186, 95% CI: 1.051-1.338, p = 0.006). Subgroup by ethnicity suggested significant association between +45T > G polymorphism and DN risk among Caucasians (OR = 1.122, 95% CI: 1.007-1.250, p = 0.038). Sensitivity analysis suggested exclusion of any single study did not materially alter the overall pooled ORs above. Future studies are needed to validate these findings.
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Lin et al. (2013) conducted a meta-analysis in diabetic nephropathy. ADIPOQ gene polymorphisms was evaluated on susceptibility to diabetic nephropathy (OR 1.186, 95% CI 1.051-1.338, p=0.006). The ADIPOQ -11391A allele was significantly associated with an increased risk of diabetic nephropathy (OR 1.186; 95% CI 1.051-1.338; P=0.006).
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