Key result
Letrozole-metformin resulted in a significantly greater reduction in ovarian artery Resistance Index compared to clomiphene-metformin (mean reduction 0.04 vs 0.02, p<0.001) in women with PCOS.
Why the study?
Does letrozole-metformin improve uterine and ovarian artery blood flow compared to clomiphene-metformin in women with PCOS-related infertility?
RCT (n=108)
Randomized
No
Does letrozole-metformin improve uterine and ovarian artery blood flow compared to clomiphene-metformin in women with PCOS-related infertility?
Letrozole combined with metformin improves uterine and ovarian blood flow more effectively than clomiphene combined with metformin in women with PCOS-related infertility.
Favors letrozole-metformin for ovarian perfusion in PCOS infertility; extends prior comparisons to Doppler resistance indices.
BackgroundPolycystic ovary syndrome (PCOS) is the most prevalence endocrine disorder in the reproductive age of women.In these patients, medications such as clomiphene citrate, letrozole and metformin are used to induce ovulation and overcome infertility. AimsThis study was done for comparing the findings of Color Doppler sonography of the uterine and ovarian arteries in women with PCOS under treatment of two drug groups of letrozole-metformin and clomiphene-metformin. MethodsIntervention-applied study was performed on 108 women with secondary infertility due to PCOS in Imam Reza Hospital of Kermanshah in 2016.Women were divided in two groups of 54 people, for investigating the effect of letrozole-metformin and clomiphene-metformin on ovarian and uterine arteries. ResultsBlood flow in the uterus and ovaries significantly increased after treatment with letrozole-metformin and clomiphenemetformin (P<0.05).However, the effect of letrozolemetformin was significantly higher than that of clomiphenemetformin on uterine and ovarian arteries Resistance Index (RI) (P<0.05). ConclusionLetrozole-metformin as well as clomiphene-metformin have a significant effect on blood flow in the uterus and ovaries.The group which received letrozole-metformin had a better response in this regard.
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Farshchian et al. (2018) conducted an RCT in Polycystic Ovary Syndrome (PCOS) with secondary infertility (n=108). Letrozole-metformin vs. Clomiphene-metformin (2,000mg metformin in combination with 100mg clomiphene) was evaluated on Difference in ovarian artery Resistance Index (RI) before and after treatment (p=<0.001). Letrozole-metformin resulted in a significantly greater reduction in ovarian artery Resistance Index compared to clomiphene-metformin (mean reduction 0.04 vs 0.02, p<0.001) in women with PCOS.
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