Key result
Fibrillin-1 genotype was significantly associated with arterial pulse pressure in healthy men aged 50 to 61 years, with the 2-4 genotype having the lowest and 2-3 the highest pressures (p=0.003).
Why the study?
Is variation in the fibrillin-1 gene associated with blood pressure in healthy middle-aged men?
Observational (n=245)
Yes
Is variation in the fibrillin-1 gene associated with blood pressure in healthy middle-aged men?
p-value: p=0.003
Variation in the fibrillin-1 gene is significantly associated with arterial pulse pressure in healthy middle-aged men.
No takes yet. Share an insight, caveat, or question.
Supports genetic contribution to pulse pressure variation; hypothesis-generating and should not yet inform clinical BP assessment.
Powell et al. (1997) conducted an observational in Healthy (n=245). Fibrillin-1 genotype vs. Between genotypes (2-2, 2-3, 2-4) was evaluated on Systolic, diastolic, and pulse pressures (p=0.003). Fibrillin-1 genotype was significantly associated with arterial pulse pressure in healthy men aged 50 to 61 years, with the 2-4 genotype having the lowest and 2-3 the highest pressures (p=0.003).
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