Induction of Lung Adenomas by Chronic Inhalation of Bis (Chloromethyl) Ether

Repeated inhalation of the vapors of bis(chloromethyl) ether and chloromethyl methyl ether at one and two ppm, respectively, and of the aerosol of urethan at approximately 138 ppm, resulted in an increase in incidence of pulmonary adenomas in strain A mice. In addition, the high toxicity of the two haloethers and the general lack of properties irritating to the upper respiratory tract in all three compounds pose an insidious industrial handling hazard.