Obesity induced renal injury: Could It be detected early?

Background: The onset of obesity-associated renal injury is insidious and asymptomatic.Therefore, finding an early marker will be extremely useful in its detection.Kidney injury molecule-1 (KIM-1) can be evaluated as an early marker for renal injury in obese children.Methods: This case control study involved two groups: a case group of 45 Egyptian overweight/obese children and a control group of 45 non-obese peers.Anthropometry and blood pressure were measured in both groups.Additionally, KIM-1 and serum creatinine levels were assessed.Results: Compared to the control group, the case group showed a significantly higher systolic (P-value 0.000) and diastolic (P-value = 0.002) blood pressure.A significantly higher serum creatinine (P=0.007) and KIM-1 (P=0.001) were also found.Conclusion: It is inferred that obesity impacts renal hemodynamics early in childhood.Thus, identifying a screening marker like KIM-1 is useful for the early diagnosis of renal injury.