Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

Iyo Koyanagi; Alvaro Carrier‐Ruiz; Pablo Vergara; Sakthivel Srinivasan; Yuki Sugaya; Masatoshi Kasuya; Tzong‐Shiue Yu; Kaspar E. Vogt; Masafumi Muratani; Takaaki Ohnishi; Sima Singh; Cátia M. Teixeira; Yoan Chérasse; Toshie Naoi; Szu‐Han Wang; Pimpimon Nondhalee; Boran A.H. Osman; Naoko Kaneko; Kazunobu Sawamoto; Steven G. Kernie; Takeshi Sakurai; Thomas J. McHugh; Masanobu Kano; Masashi Yanagisawa; Masanori Sakaguchi

doi:10.1016/j.neuron.2020.05.008

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Abstract

imaging in freely moving mice. We found that contextual fear learning recruits a population of young ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN activity. Optogenetic silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on ABN dendrites and impairs memory consolidation. These findings provide a causal link between ABN activity during REM sleep and memory consolidation.

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Koyanagi et al. (2020) studied this question.

synapsesocial.com/papers/6a9c47483a405cc3ac5d23f8 https://doi.org/10.1016/j.neuron.2020.05.008

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Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

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Abstract

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Sparse Activity of Hippocampal Adult-Born Neurons during REM Sleep Is Necessary for Memory Consolidation

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