Key result
Treatment with Psorinovo was associated with the development of progressive multifocal leukoencephalopathy and subsequent immune reconstitution inflammatory syndrome in a single patient.
Case Report (n=1)
This case report highlights a potential causal link between fumaric acid esters (Psorinovo) and the development of PML and subsequent IRIS.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to possible PML risk with Psorinovo; leaves open causality and generalizability beyond this single case.
On December 7, we noticed signs of an immune reconstitution inflammatory syndrome (IRIS) on MRI, with indications becoming more evident on December 13 (Fig. 1).We initiated treatment with intravenous methylprednisolone.Her clinical condition stabilized in early January 2013, and we observed the first signs of recovery on January 31.We believe that treatment with Psorinovo contributed to the development of PML in our patient.First, lymphopenia developed during treatment with Psorinovo and is a well known side effect. 1 Second, our patient had used no immunosuppressive medication before the onset of PML, and she was seronegative for HIV.Finally, the occurrence of IRIS after the discontinuation of Psorinovo argues in favor of a causal link.We think this case report is of special relevance since preparations of fumaric acid esters, including dimethyl fumarate, are emerging drugs that may have a broader range of therapeutic indications in the near future.
No takes yet. Share an insight, caveat, or question.
Sweetser et al. (2013) conducted a case report in Progressive multifocal leukoencephalopathy (PML) (n=1). Psorinovo was evaluated on Development of PML and IRIS. Treatment with Psorinovo was associated with the development of progressive multifocal leukoencephalopathy and subsequent immune reconstitution inflammatory syndrome in a single patient.
Synapse has enriched 10 related papers. Consider them for comparative context: