The synthesis of three potential F-ring components, variably functionalized for attachment to the chlorodiene side chain by differing chemical means, has been accomplished from D-(+)-mannose as the generic precursor.The co-discovery of the spongistatins 1 and altohyrtins 2 has stimulated considerable s ynthetic interest 3 that has eventuated in four total s yntheses. 4-7Efforts in this laboratory aimed at spongistatin 1 (1) have successfully culminated in cons truction of the complete C1-C28 s ector that houses the A/B and C/D spiroacetal subunits.
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Paquette et al. (2002) studied this question.
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