Lignans are a class of naturally occurring compounds characterized by bonding of two aryl propanoids at the 2‐position. Recently, an increasing significance of the biological activities of these compounds has been recognized. Members of 2,5‐bisaryltetrahydrofuran class of lignans are antagonists of the potent bioactive phospholipid, platelet activating factor (PAF). In this review, a survey of the occurrence, physical properties of all known bisaryltetrahydrofurans and reported biological activities as PAF antagonists is given.
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Biftu et al. (1987) studied this question.
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