The use of (phenylthio)methyl azide to build the N-methylaziridine unit and a provocative rearrangement to an imidazoledithiocarboxyl group are the crucial steps in the total synthesis of (±)-mitomycin K (3) via 1 and 2. Mitomycins of type 3 promise to provide an interesting bioorganic chemistry because of the exocyclic double bond. X = H, Y = OH, R = SC(S)-imidazole.
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Benbow et al. (1992) studied this question.
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