Key result
A low preoperative Geriatric Nutritional Risk Index was significantly associated with worse 3-year recurrence-free survival (62.1% vs 82.1%, p<0.0001) compared to a high GNRI in elderly patients with colorectal cancer.
Why the study?
Few reports have investigated recurrence factors using preoperative GNRI in CRC patients, creating a need to evaluate its association with recurrence-free and overall survival in elderly patients.
Does a low preoperative Geriatric Nutritional Risk Index predict worse recurrence-free and overall survival in elderly patients undergoing curative resection for colorectal cancer?
Cohort (n=259)
No
Does a low preoperative Geriatric Nutritional Risk Index predict worse recurrence-free and overall survival in elderly patients undergoing curative resection for colorectal cancer?
A low preoperative Geriatric Nutritional Risk Index is an independent predictor of poor recurrence-free and overall survival in elderly patients undergoing curative resection for colorectal cancer.
Low GNRI may flag higher recurrence risk in elderly CRC resection; hypothesis-generating for nutritional intervention trials.
Purpose: T The world is becoming longer-lived, and the number of elderly colorectal cancer patients is increasing. It is very important to identify simple and inexpensive postoperative predictors in elderly colorectal cancer patients. The geriatric nutritional risk index (GNRI) is a marker of systemic nutrition and is associated with poor survival in various kinds of cancers. A few reports have investigated recurrence factors using preoperative GNRI with CRC patients. This study aimed to investigate whether preoperative GNRI is associated with recurrence-free survival (RFS) and overall survival (OS) in elderly patients with CRC.Methods: This study retrospectively enrolled 259 patients with StageⅠ-Ⅲ CRC who were more than 65 years old and underwent curative surgery at a single institution in 2012–2017. We classified them into low GNRI (RFS: ≤90.5, OS ≤101.1) group and high GNRI (RFS:>90.5, OS >101.1) group.Results: Multivariable analyses showed low GNRI group was an independent risk factor for 3-year RFS (P = 0.006) and OS (P = 0.001) in the patients with CRC. Kaplan-Meier analysis showed 3-year RFS and 3-year OS were significantly worse in the low GNRI group than in high GNRI group (p = 0.001, 0.0037).Conclusion: A low-preoperative GNRI was significantly associated with a poor prognosis in elderly CRC patients.
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Hayama et al. (2021) conducted a cohort in Colorectal cancer (n=259). Low preoperative Geriatric Nutritional Risk Index (GNRI) vs. High GNRI was evaluated on 3-year recurrence-free survival (RFS) (p=<0.0001). A low preoperative Geriatric Nutritional Risk Index was significantly associated with worse 3-year recurrence-free survival (62.1% vs 82.1%, p<0.0001) compared to a high GNRI in elderly patients with colorectal cancer.
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