Synthesis and Biological Evaluation of (N‐(3‐methoxyphenyl)‐4‐((aryl‐1 H ‐1,2,3‐triazol‐4‐yl)methyl)thiomorpholine‐2‐carboxamide 1,1‐Dioxide Hybrids as Antiproliferative Agents

A series of new thirteen N‐(3‐Methoxyphenyl)thiomorpholine‐2‐carboxamide 1, 1‐dioxide derived 1, 4‐disubtituted 1, 2, 3‐triazole hybrids ( 7 a‐7 m ) were synthesized by Cu (I) catalyzed cycloaddition reaction and well characterized by 1 H NMR, 13 C NMR, FTIR, mass spectral and elemental analysis data. All the hybrid compounds were subjected to in vitro anticancer activity against three human cancer cell lines MCF‐7, Hela and A‐549 and 2‐hydroxy phenyl, 2‐methoxy phenyl and 3‐methoxy phenyl substituted ( 7 f, 7 g and 7 h) derivatives were found to possess potential antiproliferative activity.