Key result
Well-controlled type 2 diabetic patients with short-term disease had significantly reduced flow-mediated dilation (8.5% vs 15.4%) and cerebral vasomotor reactivity (39.4% vs 51.7%) compared to healthy controls.
Why the study?
Are cerebral hemodynamics and systemic endothelial function impaired in well-controlled T2DM patients with short-term disease compared to healthy controls?
Cross-Sectional (n=44)
Single-blind
No
Are cerebral hemodynamics and systemic endothelial function impaired in well-controlled T2DM patients with short-term disease compared to healthy controls?
Absolute Event Rate: 8.5% vs 15.4%
p-value: p=<0.001
Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled T2DM patients with short-term disease, suggesting early vascular dysfunction prior to marked metabolic derangement.
Early vascular impairment may occur in well-controlled short-term T2DM; hypothesis-generating and requires prospective validation.
OBJECTIVE: Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-controlled T2DM patients with short-term disease and without cardiac autonomic neuropathy (CAN). RESEARCH DESIGN AND METHODS: Twenty-six T2DM patients with short-term (4.40±4.80 years) and well-controlled (HbA1C = 6.71±1.29%) disease, without any complications, treated with diet and/or metformin, were consecutively recruited. Eighteen controls, comparable by sex and age, were enrolled also. RESULTS: FMD and shear rate FMD were found to be reduced in T2DM subjects with short-term disease (8.5% SD 3.5 and 2.5 SD 1.3, respectively) compared to controls (15.4% SD 4.1 and 3.5 SD 1.4; p<.001 and p<.05). T2DM patients also displayed reduced VMR values than controls (39.4% SD 12.4 vs 51.7%, SD 15.5; p<.05). Sympatho-vagal balance was not different in T2DM patients compared to healthy subjects. FMD and shear rate FMD did not correlate with VMR in T2DM patients or in controls (p>.05). CONCLUSIONS: In well-controlled T2DM patients with short-term disease cerebral hemodynamics and systemic endothelial function are altered while autonomic balance appeared to be preserved.
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Palazzo et al. (2013) conducted a cross-sectional in Type 2 diabetes mellitus (n=44). Type 2 diabetes mellitus (short-term, well-controlled) vs. Healthy controls was evaluated on Flow-mediated dilation (FMD) (p=<0.001). Well-controlled type 2 diabetic patients with short-term disease had significantly reduced flow-mediated dilation (8.5% vs 15.4%) and cerebral vasomotor reactivity (39.4% vs 51.7%) compared to healthy controls.
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