Catalytic Asymmetric Michael Addition/Cyclization of Isothiocyanato Oxindoles: Highly Efficient and Versatile Approach for the Synthesis of 3,2′‐Pyrrolidinyl Mono‐ and Bi‐spirooxindole Frameworks

A-spiro-ing to greatness: The catalytic asymmetric Michael addition/cyclization of isothiocyanato oxindoles has been realized. This versatile approach provides an easy and highly efficient way to access not only the enantioselective synthesis of 3,2′-pyrrolidinyl spirooxindole frameworks, but also the construction of enatiomerically enriched bi-spirooxindoles containing three contiguous stereocenters and two spiro-quaternary centers (see scheme).