The manner in which new drugs are studied has changed drastically during the past 30 years. Certainly, the effective administration of the Food, Drug and Cosmetic Act has been a factor in this, but the importance of the gain in our basic knowledge of drug actions and the effect of intense competition in the pharmaceutic field have also played important roles. Safety evaluation has almost reached the status of a separate specialty.
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J.T. LITCHFIELD (1962) studied this question.