Key result
Bacterial lipopolysaccharide-induced endotoxemia significantly depressed myocardial and plasma MMP-2 activity and rapidly elevated plasma MMP-9 activity, which correlated inversely with blood pressure.
Why the study?
Does bacterial lipopolysaccharide (LPS) alter myocardial and plasma matrix metalloproteinase activities in male Sprague-Dawley rats?
RCT
randomized
Does bacterial lipopolysaccharide (LPS) alter myocardial and plasma matrix metalloproteinase activities in male Sprague-Dawley rats?
Endotoxemia induces rapid changes in myocardial and plasma MMP activities, suggesting increased circulating MMP-9 may contribute to endotoxemic cardiovascular dysfunction.
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Lalu et al. (2004) conducted an RCT in endotoxemia. bacterial lipopolysaccharide (LPS) vs. vehicle (pyrogen-free water) was evaluated on myocardial and plasma matrix metalloproteinase (MMP) activities and blood pressure. Bacterial lipopolysaccharide-induced endotoxemia significantly depressed myocardial and plasma MMP-2 activity and rapidly elevated plasma MMP-9 activity, which correlated inversely with blood pressure.
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