Key result
The CTNND1 755 T>G polymorphism G allele was significantly associated with an increased risk of pancreatic carcinoma in a Chinese population (OR 1.696).
Why the study?
Does the CTNND1 755 T>G polymorphism increase the risk of pancreatic carcinoma in a Chinese population?
Case-Control (n=302)
No
Does the CTNND1 755 T>G polymorphism increase the risk of pancreatic carcinoma in a Chinese population?
Odds Ratio: 1.696 (95% CI 1.038–2.275)
Absolute Event Rate: 30.3% vs 11.9%
p-value: p=0.012
The CTNND1 755 T>G polymorphism is associated with an increased risk of pancreatic carcinoma in the Chinese population.
Supports genetic risk marker investigation in pancreatic carcinoma; hypothesis-generating and should not yet change clinical practice.
OBJECTIVE: gene, which is associated with the risk of pancreatic carcinoma in Chinese. METHODS: 755 T>G genotypes were determined by PCR-RFLP in 122 pancreatic carcinoma patients and 180 healthy controls matched for age and sex, who did not receive radiotherapy or chemotherapy for newly diagnosed and histopathologically confirmed pancreatic carcinoma. RESULTS: In control subjects, the frequency of T/T and G/T genotypes, and T and G alleles was 79.4%, 17.2%, 88.1%, and 11.9%, respectively. The distribution of genotypes and allelotypes in the pancreatic carcinoma patients was significantly different from that in the controls (P = 0.007, P = 0.012). Combined GG and GT genotypes were found to have a higher OR in male pancreatic carcinoma patients and the group under the age of 70 years (males: OR, 1.409; 95%CI, 0.912~1.921; under 70 years: OR 1.626; 95% CI, 0.878~2.312). This study also showed a distinct difference in the distribution of P120ctn and single nucleotide polymorphisms (SNPs) between Chinese and Canadian (11.9% vs. 3.9%, P = 0.008). CONCLUSION: promoter SNPs is diverse in ethnic populations.
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Wang et al. (2016) conducted a case-control in Pancreatic carcinoma (n=302). CTNND1 755 T>G polymorphism (G allele) vs. T allele / healthy controls was evaluated on Risk of pancreatic carcinoma (OR 1.696, 95% CI 1.038-2.275, p=0.012). The CTNND1 755 T>G polymorphism G allele was significantly associated with an increased risk of pancreatic carcinoma in a Chinese population (OR 1.696).
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