Thoracic gas volume (TGV) and specific airway conductance (SGaw) were measured in 6 infants, 21-42 weeks of age, who had been mechanically ventilated during the neonatal period. SGaw was significantly decreased while TGV was normal. Administration of a nebulized beta 2-sympathomimetic stimulant did not improve lung function. It is concluded that inhalation of beta 2 stimulant drugs is not effective in improving airway obstruction in infants with postventilation-elevated airway resistance and that this is likely to be of structural origin.
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Tal et al. (1982) studied this question.