Poly(5‘-acryloyluridine) has been shown to act as a template in the radical polymerization of the complementary 5‘-acryloyladenosine in the presence of the noncomplementary 5‘-acryloyluridine. The template was synthesized by polymerizing 5‘-acryloyluridine using AIBN as the initiator. The 5‘-acryloylnucleosides were synthesized by regiospecific acylation of adenosine and uridine at the 5‘-position using the enzyme Candida antarctica lipase 435 (CAL 435). The remaining hydroxyl groups were protected as silyl ethers to increase the solubility in nonpolar solvents.
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Khan et al. (1999) studied this question.
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