Key result
Patients with pulmonary hypertension due to congenital heart defects had lower blood saturation (90.1% vs 97.2%, P<0.05) and altered microcirculation compared to controls.
Why the study?
What is the state of skin microcirculation in patients with pulmonary hypertension due to congenital heart defects compared to controls?
Case-Control (n=50)
What is the state of skin microcirculation in patients with pulmonary hypertension due to congenital heart defects compared to controls?
Patients with pulmonary hypertension due to congenital heart defects exhibit compensatory changes in skin microcirculation, including lower blood saturation and higher vasomotion amplitudes, likely due to systemic hypoxia.
Answers are grounded in this paper and cite their sources.
May indicate compensatory microcirculatory changes in hypoxic congenital PH; hypothesis-generating and requires prospective validation.
Aim - to assess the state of microcirculation in the skin in patients with pulmonary hypertension due to congenital heart defects (PH-CHD). Material and methods. The study was performed using laser Doppler flowmetry and capillaroscopy in 25 patients with PH-CHD and a control group (n=25). Results. Patients with PH-CHD have a low blood saturation of 90.1 % and 97.2 % (<0.05), a high amplitude of myogenic vasomotions of 0.49 PU and 0.26 PU (<0.05), pulsatile 0.14 PU and 0.11 PU (<0.05) and respiratory associated blood flow fluctuations of 0.24 PU and 0.13 PU (<0.05), respectively. Against this background, there is no evidence of fluid retention in the tissue. Conclusions. Changes in microcirculation are compensatory in the conditions of systemic hypoxia, caused by violations of hemodynamics in the heart and a small circle of blood circulation.
No takes yet. Share an insight, caveat, or question.
Долгова et al. (2018) conducted a case-control in Pulmonary hypertension due to congenital heart defects (n=50). Pulmonary hypertension due to congenital heart defects vs. Control group was evaluated on Blood saturation (p=<0.05). Patients with pulmonary hypertension due to congenital heart defects had lower blood saturation (90.1% vs 97.2%, P<0.05) and altered microcirculation compared to controls.
Synapse has enriched 10 related papers. Consider them for comparative context: