Key result
Annual publications on gut microbiota and functional constipation increased from 29 in 2013 to 252 in 2023, with China, the United States, and Japan leading global research output.
Why the study?
Functional constipation is associated with gut microbiota imbalances, but despite growing interest, a thorough analysis of research trends in this area is missing.
Systematic Review (n=1,405)
This bibliometric analysis maps the global research landscape on gut microbiota and functional constipation, highlighting key authors, institutions, and a shift toward probiotics and gut-brain axis therapies.
Surging publications on gut microbiota in functional constipation extend probiotic and gut-brain axis research; clinical adoption remains premature pending interventional trials.
Background: Functional constipation (FC) negatively impacts quality of life and is associated with gut microbiota (GM) imbalances. Despite the growing interest in this area, a thorough analysis of research trends is missing. This study uses bibliometric methods to assess the global research on GM's role in FC, pinpointing key topics, impactful studies, and prominent researchers to guide future research and identify gaps. Methods: In our study, we conducted a performance analysis and science mapping using bibliometric indicators such as publication trends, author and institutional contributions, productivity, impact, keyword analysis, and collaboration networks. We employed software tools like VOSviewer, Biblioshiny, CiteSpace, and SCImago Graphica to automate the assessment of metrics including country, institutional, and journal distribution, authorship, keyword frequency, and citation patterns. Results: From 2013 to 2024, annual publications on GM and FC rose from 29 to 252, with a slight decrease to 192 in 2024. Average citations per publication peaked at 11.12 in 2021, declining to 6.43 by 2024. China led in research output (37.8%), followed by the United States (14.4%) and Japan (7.5%). Bibliometric analysis identified key authors like CHEN W and ZHANG H, with 30 and 27 articles, respectively. Jiangnan University and Harvard University were top contributors, with 131 and 81 articles. Keywords analysis revealed "constipation," "gut microbiota," and "probiotic" as central themes, with a shift toward "gut microbiota" and "intestinal flora" in recent years. This study provides a comprehensive overview of the research landscape, highlighting leading authors, institutions, and evolving research priorities in the field. Conclusion: Our review synthesizes current GM and FC research, guiding future studies. It suggests exploring GM in various GI disorders, the impact of lifestyle and drugs on GM, advanced research techniques, and probiotics/prebiotics for FC. There's also a focus on therapies targeting GM's effect on the gut-brain axis, paving the way for improved FC management.
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Ong et al. (2024) conducted a systematic review in Functional constipation (n=1,405). Bibliometric analysis was evaluated on Annual publication volume and bibliometric trends. Annual publications on gut microbiota and functional constipation increased from 29 in 2013 to 252 in 2023, with China, the United States, and Japan leading global research output.
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