COX and LOX inhibitors analogous to 2-arylpropanoic acids have been synthesized (general route is shown below) and can be viewed as mimetics of arachidonic acid. Remarkably, even medium-sized cycloalkanones reacted almost quantitatively with zinc cuprates. Interesting differences in pharmacological activities related to ring size were observed.
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Greve et al. (1996) studied this question.
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