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Red cell substitutes: Heme proteins that bind oxygen also bind NO, so designing safe and effective heme-based transfusion alternatives that have low affinities for NO but bind O2 effectively for delivery remains a significant challenge. Here we show that NO scavenging by hemoglobin may be counteracted by the nitrite reductase activity of hemes in modified proteins.
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Lui et al. (2010) studied this question.
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