Selective precipitation of the product alkoxide 2′ is observed at higher conversions of substrate in the asymmetric autocatalytic alkylation of pyrimidyl aldehyde 1. Enrichment or depletion of the enantiomeric excess in solution can result, depending on the solvent employed in the reaction. Asymmetric amplification may be effected by a synergistic combination of chemical and physical processes, leading to a homochiral reaction environment.
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Buono et al. (2004) studied this question.
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