Construction and Screening of a 2‐Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms across Order, Class, and Phylum

A team of three: 2-Aminoimidazole, triazole, and tether units together resulted in conjugates (see picture, n=4–6 for the most active compounds) that are capable of inhibiting and dispersing bacteria biofilms without inducing bacterial death. Such biofilms have been implicated in a plethora of medical problems, including infection of implanted medical devices and the mortality of cystic fibrosis patients.