Chronic muco-cutaneous candidiasis and oral neoplasia

Two patients with chronic muco-cutaneous candidiasis who subsequently developed oral neoplasia are presented. In both cases the tumours appeared in the fourth decade of life. The natural history of these tumours was not unique but varied from the norm. In one patient there was an obvious propensity for metastasis; in the other, three separate tumours evolved. An argument could be made to link the unusual features evident in these two cases with the state of altered immunity known to occur in chronic muco-cutaneous candidiasis, although the suggestion is speculative.