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Allergic reactions to toothpaste flavours are infrequent: only 5 cases in a 26‐year period among 46,000 Copenhagen eczema patients (9) and 7 cases in a 6‐year period at Gentofte Hospital (3). Spearmint is used in almost every brand of toothpaste as a flavour, together with other flavouring ingredients such as menthol, peppermint, anethole, eugenol and cinnamic aldehyde. It is also used in chewing gum, medicines, etc.
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Skrebova et al. (1998) studied this question.
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