Hyperaspine (1a), isolated from the European Coccinellidae Hyperaspis campestris, isthe first representative of a new type of ladybird alkaloids having a 3‐oxaquinolizidine skeleton. A new total synthesis of (±)‐hyperaspine starting from protected piperidin‐4‐one has been achieved. The absolute configuration of the natural alkaloid was unequivocally established to be 3S,4aS,6R,8S by HPLC analyses on a chiral column. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)
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Dooms et al. (2005) studied this question.
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