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An implantable glucose sensor must be free of baseline and sensitivity drift. To our knowledge, a drift-free glucose sensor with fast response time is not currently available. We are therefore proposing a miniature extracorporeal glucose sensor with access to the vascular system as a practical step toward implantation. This sensor could use existing technology to form the basis of a patient-wearable closed-loop system.
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Oberhardt et al. (1982) studied this question.