7 (1JrJJJJ jd JJJ 74rJ 4e00cdCeGre007Coee gcCeU0r05-8573 5JeeorerJCeJerbJerfd0ec 7 7(UJJ7lJJ 0rjO5-57j hC)7 gG JJ(7-g0 U02(565-087tJ KeywordsPOly(ethyleneglycol)-blbck-POly(lactide)copolymeIIDDSPOlymericmicelles COre-POlymerizationPlasmajetsdielectricbarrierdischargeplasma 1Introduction Polymericmicellesfbrmedinaqueousmedia through self-aSSembly of poly(ethylene glycol)-block-POly(lactide) Copolymers (PEG-b-PLA)have been extensively studied as drug delivery carriersbecause PEG-b-PLA micelles possesslng FDA-aPPrOVed polymer COmPOnentS Showed high biocompatibilityand applicablebiodegradability1-3Theirhydrophilic PEGshellsserveaSabruShtoavoidtheprotein adsorptlOnandsubsequentnon-SPeCincuptakeby reticuloendothelial systems (RES) after intra-VenOuSlrUeCtionand their hydrophobic PLA cores accommodate drugS With a high loadingefnciency The PEG-b-PLA micelles are known to POSSeSS a relativelylow critical association COnCentration(CAC)valueandexhibitSlow dissociation behavior difftrentfrom the mlCelles COmPOSed oflow molecular weight surfactant even under dilute conditions4Howeverthe PhysICal assemble force1eintemOlecular hydrophobicandorvanderalsinteractionaS themaindrivlngforceto fbrmthemicellewith COre-Shell struCture may nOt be enough to maintainits stableformunderinvivo conditions
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Sumitani et al. (2009) studied this question.
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