Photosensitizers with high photocleavage ability are urgently needed to improve photodynamic therapy efficacy. Herein, a supramolecular complex was constructed through host-guest self-assembly using hexa-β-CD-appended ruthenium polypyridyl (6CD-Ru) and adamantane-modified anthracene (ADA-AN) in water. The targeted DNA-intercalation of peripheral anthracenes can remarkably enhance photocleavage ability and antitumor activity of the complex irradiated with visible light.
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Cheng et al. (2018) studied this question.
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