Key result
Two cases of myofibrillar myopathies due to BAG3 and LDB3 mutations demonstrated distinct clinical presentations, with the LDB3 patient responding to intermittent steroids and strengthening exercises.
Case Report (n=2)
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This case series highlights the diverse clinical presentations, genetic mutations, and management strategies in pediatric patients with myofibrillar myopathies.
We describe two cases of myofibrillar myopathies, due to different gene mutations. The first was a girl with cardiomyopathy and sensory axonal neuropathy that underwent cardiac transplantation at 15 years and suffers from rotatory scoliosis due to BAG3 mutation. The second is a male patient, with evident limb-girdle weakness since age 3. Two muscle biopsies were performed at ages 3 and 15, with muscle MRI, and LDB3 gene sequence analysis also carried out. Muscle biopsies revealed the presence of dystrophic changes in the first biopsy and myopathic abnormalities in the second, and the MRI images of the lower limbs showed an asymmetrical involvement in the thigh of quadriceps muscles and in the calf of gastrocnemius muscles. The patient was responsive to treatment with an intermittent steroid regimen and muscle-strengthening exercises. Considerations on both muscle-bone interaction and psychological and socioeconomic conditions are carried out for both cases.
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Angelini et al. (2023) conducted a case report in Myofibrillar myopathies (n=2). Two cases of myofibrillar myopathies due to BAG3 and LDB3 mutations demonstrated distinct clinical presentations, with the LDB3 patient responding to intermittent steroids and strengthening exercises.
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