(+)‐2‐(4‐Methoxy‐5‐phenyl‐3‐thienyl)propionic acid (1) was obtained by asymmetric hydrogenation of 2‐(4‐methoxy‐5‐phenyl‐3‐thienyl)acrylic acid (11) in 97% yield and with an optical purity of 88% using Kagan's catalyst. The racemic acid 1 was also prepared by an independent route and resolved by classical techniques.
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Stoll et al. (1974) studied this question.
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