Haemopoiesis continued for over 2 months in organ culture of embryonal mouse liver, and haemopoietic stem cells (CFUs) capable of DNA‐synthesis were found in it all that time. Between the 10th and 40th day the number of stem cells in the culture was sustained in a steady state. Both in normal and in regenerating adult bone marrow haemopoiesis ceased within a short time in the culture. Induction of proliferation in haemopoietic stem cells combined with undamaged or improved micro‐environment resulted in a little better maintenance of CFUs in the adult bone marrow culture, The results are discussed in the light of current concepts of haemopoietic stem cell regulation.
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Chertkov et al. (1974) studied this question.
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