Key result
Nitric oxide modulates metalloregulatory proteins, such as the iron regulatory protein, by interacting with metal clusters at critical allosteric sites during cellular stress responses.
Population
Cells with inducible nitric oxide synthase and metalloregulatory proteins
Design
Review
Authors
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May position NO as cellular stress signal in metal regulation; leaves open cardiovascular translation pending targeted studies.
Nitric oxide may act as a crucial cellular stress signal by modulating the function of metalloregulatory proteins via interaction with metal clusters.
Drapier et al. (1996) reported a review. Nitric oxide was evaluated. Nitric oxide modulates metalloregulatory proteins, such as the iron regulatory protein, by interacting with metal clusters at critical allosteric sites during cellular stress responses.
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