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(+)-Streptazolin synthesis revisited: The key reaction in the 11-step total synthesis of (+)-streptazolin (3), which starts from D-mannitol diacetonide, is the palladium-catalyzed reductive cyclization of two alkyne arms in 1 to provide the desired 1,3-diene 2 with the correct defined geometry. TBS=tert-butyldimethylsilyl.
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Trost et al. (2004) studied this question.
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