Lyme Disease

In the Clinic7 August 2012Lyme DiseaseLinden T. Hu, MD, Deborah Cotton, MD, MPH, Darren Taichman, MD, PhD, and Sankey Williams, MDLinden T. Hu, MD, Deborah Cotton, MD, MPH, Darren Taichman, MD, PhD, and Sankey Williams, MDAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-157-3-201208070-01002 SectionsSupplemental MaterialAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Editor's Note: This issue of In the Clinic has been updated.Today, Lyme disease is the most common vector-borne disease in the US, with over 22 500 confirmed cases in 2010. Borrelia burgdorferi, a spirochete, is transmitted by the bite of infected Ixodes ticks. These ticks have a 3-stage lifecycle (larvae, nymph, and adult) and take 1 blood meal at each stage. They become infected by feeding on an infected wild animal—typically white-footed mice, voles, chipmunks, or birds—during the larval feeding. 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Hu, MD; Deborah Cotton, MD, MPH; Darren Taichman, MD, PhD; Sankey Williams, MD PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byVector-Borne InfectionsTick-Borne Diseases in the United StatesMetamorphoses of Lyme disease spirochetes: phenomenon of Borrelia persistersLyme DiseasePrimary Human Microglia Are Phagocytically Active and Respond to Borrelia burgdorferi With Upregulation of Chemokines and CytokinesHealth Related Experiences of Los Angeles County, California Residents with Chronic Lyme DiseaseDesign of a Lyme Disease Vaccine as an Active Learning Approach in a Novel Interdisciplinary Graduate-Level CourseBrave New Worlds: The Expanding Universe of Lyme DiseaseTechnical and clinical validation of three commercial real-time PCR kits for the diagnosis of neuroborreliosis in cerebrospinal fluid on three different real-time PCR platformsExpression of C-Reactive Protein and Serum Amyloid A in Early to Late Manifestations of Lyme DiseaseEpitope-Specific Evolution of Human B Cell Responses to Borrelia burgdorferi VlsE Protein from Early to Late Stages of Lyme DiseaseBorrelia burgdorferi, the Causative Agent of Lyme Disease, Forms Drug-Tolerant Persister CellsAssociation of Immune Response to Endothelial Cell Growth Factor With Early Disseminated and Late Manifestations of Lyme Disease but Not Posttreatment Lyme Disease Syndrome: Figure 1.Arthropod-borne arthritidesRedaksjonen svarer:Lyme Disease: A Review of Its Epidemiology, Evaluation, and TreatmentDiagnostik und Therapie der Lyme-ArthritisLyme BorreliosisInsight into the Pathogenesis of Lyme DiseaseDiagnosing and managing Lyme diseaseBB0347, from the Lyme Disease Spirochete Borrelia burgdorferi, Is Surface Exposed and Interacts with the CS1 Heparin-Binding Domain of Human FibronectinChoosing wisely: The American College of Rheumatology's top 5 list of things physicians and patients should questionLyme disease 7 August 2012Volume 157, Issue 3 Page: ITC2-1 Keywords Antibiotics Antigens Arthritis Doxycycline Infectious diseases Lyme disease Meningitis Paralysis Prophylaxis Ticks ePublished: 7 August 2012 Issue Published: 7 August 2012 Copyright & PermissionsCopyright © 2012 by American College of Physicians. 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