Key result
Glucose-insulin-potassium infusion significantly reduced pacing-induced ST depression (1.4 vs 2.4 mm) and LVEDPi (16 vs 23 mm Hg) compared to the pre-GIK state.
Why the study?
Does glucose-insulin-potassium infusion reduce atrial pacing-induced myocardial ischemia in patients with and without coronary artery disease?
Does glucose-insulin-potassium infusion reduce atrial pacing-induced myocardial ischemia in patients with and without coronary artery disease?
Glucose-insulin-potassium infusion is well tolerated and reduces physiological markers of pacing-induced myocardial ischemia.
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May attenuate pacing-induced ischemia markers; hypothesis-generating for GIK in CAD, pending outcome trials.
Chiong et al. (1976) studied Myocardial ischemia (n=18). Glucose-insulin-potassium infusion (GIK) vs. Pre-GIK state was evaluated on Atrial pacing-induced angina, ST depression, LVEDPi, and lactate metabolism. Glucose-insulin-potassium infusion significantly reduced pacing-induced ST depression (1.4 vs 2.4 mm) and LVEDPi (16 vs 23 mm Hg) compared to the pre-GIK state.
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